Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery
- PDF / 1,685,443 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 43 Downloads / 216 Views
ORIGINAL ARTICLE
Postoperative prognostic nutritional index as a prognostic factor after non‑small cell lung cancer surgery Kazuki Hayasaka1,2 · Satoshi Shiono1 · Katsuyuki Suzuki1 · Makoto Endoh1 · Yoshinori Okada2 Received: 3 January 2020 / Accepted: 10 April 2020 © The Japanese Association for Thoracic Surgery 2020
Abstract Objective The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor. Methods Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. PrePNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis. Results We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (P
Data Loading...
