Markers of small cell lung cancer
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Review
Markers of small cell lung cancer Tarvinder K Taneja and SK Sharma* Address: Division of Pulmonary and Critical Care Medicine; Department of Medicine, All India Institute of Medical Sciences, New Delhi-110029, India Email: Tarvinder K Taneja - [email protected]; SK Sharma* - [email protected] * Corresponding author
Published: 05 May 2004 World Journal of Surgical Oncology 2004, 2:10
Received: 29 March 2004 Accepted: 05 May 2004
This article is available from: http://www.wjso.com/content/2/1/10 © 2004 Taneja and Sharma; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
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Abstract Lung cancer is the number one cause of cancer death; however, no specific serum biomarker is available till date for detection of early lung cancer. Despite good initial response to chemotherapy, small-cell lung cancer (SCLC) has a poor prognosis. Therefore, it is important to identify molecular markers that might influence survival and may serve as potential therapeutic targets. The review aims to summarize the current knowledge of serum biomarkers in SCLC to improve diagnostic efficiency in the detection of tumor progression in lung cancer. The current knowledge on the known serum cytokines and tumor biomarkers of SCLC is emphasized. Recent findings in the search for novel diagnostic and therapeutic molecular markers using the emerging genomic technology for detecting lung cancer are also described. It is believed that implementing these new research techniques will facilitate and improve early detection, prognostication and better treatment of SCLC.
Introduction Lung cancer is the most common cancer world over. It is classified into small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). They occur with a frequency of 20% and 80% respectively [1]. The aggressive nature of SCLC with frequent and early metastases accounts for a dismal 5-year survival rate of
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