Analysis of maternal and perinatal determinants of allergic sensitization in childhood
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llergy, Asthma & Clinical Immunology Open Access
RESEARCH
Analysis of maternal and perinatal determinants of allergic sensitization in childhood Samuel Schäfer1,2 , Anthony Liu2* , Dianne Campbell3,4 and Ralph Nanan2
Abstract Background: Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preventing or predisposing the development of allergies. The aim of this study therefore was to identify independent perinatal factors associated with allergic sensitization in childhood. Methods: In a single center retrospective case-cohort study electronic obstetric medical records and available skin prick testing results of children were analyzed. For the analysis 286 skin prick test positive (sensitized) children [median (IQR): 3.47 (1.70–7.34) years] were compared with data from all remaining live births in the obstetric cohort (n = 66,583). Results: Sensitized children more frequently had a mother born in Asia (19.1% vs. 10.2%; P 35 years; OR: 1.912; P
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