Androgen Action in Prostate Cancer
This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status
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Donald Tindall
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James Mohler
Editors
Androgen Action in Prostate Cancer
Editors Donald Tindall 200 1st Street SW., Rochester MN 55905 USA [email protected]
James Mohler Elm and Carlton Streets Buffalo NY 14263 USA [email protected]
ISBN 978-0-387-69177-0 e-ISBN 978-0-387-69179-4 DOI: 10.1007/978-0-387-69179-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2008942188 # Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Introduction: Proper Nomenclature Facilitates Clinical and Translational Research in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 James L. Mohler and Donald J. Tindall Part I: The Role of Androgens in Developement of the Normal Prostate and Progression of Prostate Cancer Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Historical Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, and Richard A. Hiipakka Clinical Progression to Castration-Recurrent Prostate Cancer . . . . . . . . . . . . . 57 Mark Pomerantz and Philip Kantoff Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Shuyuan Yeh, Yuanjie Niu, Hiroshi Miyamoto, Tamin Chang, and Chawnshang Chang Imaging Androgen Receptor Function In Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Michael Carey and Lily Wu Part II: Androgen Metabolism Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer . . . . . . . . . . . . . . . . 123 Steven P. Balk
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Contents
Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141 Juergen K.V. Reichardt and Ann W. Hsing Effect of Steroid 5a-Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 Lynn N. Thomas and Roger S. Rit
