Angiogenesis Inhibition
Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances
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Managing Editors
P. M. Schlag, Berlin
H.-J. Senn, St. Gallen
Associate Editors
P. Kleihues, Zürich F. Stiefel, Lausanne B. Groner, Frankfurt A. Wallgren, Göteborg Founding Editor
P. Rentchnik, Geneva
180
Rüdiger Liersch • Wolfgang E. Berdel Torsten Kessler (Eds.)
Angiogenesis Inhibition
13
Dr. Torsten Kessler Department of Medicine Hematology/Oncology University Hospital Münster Albert-Schweitzer-Str. 33 48129 Münster Germany [email protected]
Editors Dr. Rüdiger Liersch Department of Medicine Hematology/Oncology University Hospital Münster Albert-Schweitzer-Str. 33 48129 Münster Germany [email protected] Prof. Dr. Wolfgang E. Berdel Department of Medicine Hematology/Oncology University Hospital Münster Albert-Schweitzer-Str. 33 48129 Münster Germany [email protected]
ISBN: 978-3-540-78280-3
e-ISBN: 978-3-540-78281-0
DOI: 10.1007/978-3-540-78281-0 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009933610 © Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudioCalamar Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Judah Folkman . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 1
2
Angiopoietins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Yvonne Reiss
3
2.1 2.2
3
2.3 2.4 2.5
3
Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Importance of the Angiopoietin/Tie System During Developmental Angiogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Angiopoietins and Tumor-Associated Angiogenesis . . . . . . . . . . . Therapeutic Implications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conc
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