Angiotensin-(1-7) A Comprehensive Review
This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of an
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Angiotensin-(1-7)
Robson Augusto Souza Santos Editor
Angiotensin-(1-7) A Comprehensive Review
Editor Robson Augusto Souza Santos Universidade Federal de Minas Gerais Belo Horizonte, MG Brazil
ISBN 978-3-030-22695-4 ISBN 978-3-030-22696-1 (eBook) https://doi.org/10.1007/978-3-030-22696-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Acknowledgment
I would like to acknowledge Prof. Marco Antonio Peliky Fontes for all his assistance in communicating with the authors of this book. His help was instrumental for accomplishing this task. This book was written in part during my senior fellowship at the Max Delbrück Center under the support of the Alexander von Humboldt Foundation (Georg Forster Research Award). The assistance of Stephanie Viana is also acknowledged. Special thanks to the Foundation for Research Support of the State of Minas Gerais (FAPEMIG), National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel (CAPES).
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Introduction
Angiotensin-(1-7) is a heptapeptide formed from angiotensin I or angiotensin II by the action of endo- or carboxypeptidases, especially ACE2, neutral-endopeptidase (NEP), prolylendopeptidase (PEP), and thimet oligopeptidase, reviewed in Chappell et al. [1] and Santos et al. [2]. This book addresses many aspects of angiotensin (1-7). Its history started against a background of a strong dogma: the concept that angiotensin II is the only biologically active peptide of the renin-angiotensin system. The research on angiotensin-(1-7) was a groundbreaker leading to a considerable advance in our understanding of the still enigmatic, r
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