Total Marrow Irradiation A Comprehensive Review
This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to p
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Total Marrow Irradiation
Jeffrey Y. C. Wong • Susanta K. Hui Editors
Total Marrow Irradiation A Comprehensive Review
Editors Jeffrey Y. C. Wong Department of Radiation Oncology City Of Hope National Medical Center Duarte, CA USA
Susanta K. Hui Department of Radiation Oncology City Of Hope National Medical Center Duarte, CA USA
ISBN 978-3-030-38691-7 ISBN 978-3-030-38692-4 (eBook) https://doi.org/10.1007/978-3-030-38692-4 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Total Marrow Irradiation: Redefining the Role of Radiotherapy in Bone Marrow Transplantation�������������������������������� 1 Jeffrey Y. C. Wong 2 Implementation of Targeted Total Body Irradiation as a Bone Marrow Transplant Conditioning Regimen: A Review�������� 29 A. Liu, C. Han, and J. Neylon 3 Radiobiologic Factors to Consider with Total Marrow Irradiation�������������������������������������������������������������������������������������������������� 47 Susanta K. Hui and Guy Storme 4 Dose Escalation of Total Marrow and Lymphoid Irradiation in Advanced Acute Leukemia ���������������������������������������������� 69 Anthony Stein 5 Reduced Intensity Conditioning Regimens in Combination with Total Marrow and Lymphoid Irradiation �������������������������������������� 77 Joseph Rosenthal 6 Total Marrow Irradiation and Total Lymphoid Irradiation in Lymphoma and Advanced Hematologic Malignancies: The Genoa Experience������������������������������������������������������������������������������ 89 Alida Dominietto and Stefano Vagge 7 Total Marrow/Lymphoid Irradiation in the Conditioning Regimen for Haploidentical T-Cell-Depleted
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