Animal Models of Behavior Genetics
This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-s
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Jonathan C. Gewirtz Yong-Kyu Kim Editors
Animal Models of Behavior Genetics
Advances in Behavior Genetics
Series Editor Yong-Kyu Kim
More information about this series at http://www.springer.com/series/10458
Jonathan C. Gewirtz • Yong-Kyu Kim Editors
Animal Models of Behavior Genetics
Editors Jonathan C. Gewirtz Department of Psychology University of Minnesota Minneapolis, MN, USA
Yong-Kyu Kim Janelia Research Campus Howard Hughes Medical Institue Ashburn, VA, USA
Advances in Behavior Genetics ISBN 978-1-4939-3775-2 ISBN 978-1-4939-3777-6 DOI 10.1007/978-1-4939-3777-6
(eBook)
Library of Congress Control Number: 2016938080 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
This book is dedicated to the memory of Irving Gottesman, who epitomized the endophenotypes of kindness and wisdom.
Preface
When the editors of this book were in graduate school in the early 1990s studying the biological basis of behavior in rats (JCG) and Drosophila (YKK), the availability of new approaches in molecular biology and genetics brought about a nearexponential growth in our capacity to explore the nervous system of invertebrate and vertebrate species. And it was around that time that a new form of an old word entered the lexicon of behavioral neuroscience: the noun, “phenotype,” had transformed itself into a verb. Whereas “genotyping” means to identify the sequence of nucleotides in DNA, “phenotyping” came to refer to the task of identifying the structural, physiological, and behavioral consequences of genotypic variations. To these ends, new facilities were built with the express purpose of characterizing the behavior of genetically altered mice. These developments reflected recognition among geneticists and neurobiologists that behavior was an important endpoint of genotypic varia
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