Anti-neuroinflammatory Effect of a Novel Caffeamide Derivative, KS370G, in Microglial cells
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Anti-neuroinflammatory Effect of a Novel Caffeamide Derivative, KS370G, in Microglial cells Dah-Yuu Lu & Bor-Ren Huang & Wei-Lan Yeh & Hsiao-Yun Lin & Shiang-Suo Huang & Yu-Shu Liu & Yueh-Hsiung Kuo
Received: 22 March 2013 / Accepted: 7 May 2013 # Springer Science+Business Media New York 2013
Abstract Accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in several neurodegenerative disorders. Therefore, development of methods for microglial inhibition is considered an important strategy in the search for neuroprotective agents. Caffeic acid phenethyl ester (CAPE) is distributed wildly in nature, but rapid decomposition by esterase leads to its low bioavailability. In this study, we investigated the effects of KS370G, a novel caffeic acid phenylethyl amide, on microglial activation. KS370G significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia. Furthermore, D.
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