Antibiotic prophylaxis in perioperative period of percutaneous nephrolithotomy: a systematic review and meta-analysis of
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ORIGINAL ARTICLE
Antibiotic prophylaxis in perioperative period of percutaneous nephrolithotomy: a systematic review and meta‑analysis of comparative studies Junjie Yu2 · Baoyu Guo1,2 · Jiangquan Yu3 · Tian Chen1 · Xue Han4 · Quan Niu1,2 · Shigao Xu2 · Zhe Guo1,2 · Qun Shi2 · Xinxin Peng1,2 · Zhexun Deng1,2 · Penglei Yang1,3 Received: 25 May 2019 / Accepted: 20 September 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Objective To explore the efficacy of antibiotic prophylaxis in perioperative period of percutaneous nephrolithotomy (PCNL) by conducting a systematic review and meta-analysis. Materials and methods A systematic literature search using Pubmed, Embase, and the Chinese SinoMed, CNKI, WanFang and VIP databases was performed to find comparative studies on the efficacy of different antibiotic prophylaxis strategies in PCNL for preventing postoperative sepsis. The last search was conducted on 21 April 2019. All selected articles were reviewed independently by two, and in case of discordance, three reviewers. Summarized unadjusted odds ratios (ORs) or risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the efficacy of different antibiotic prophylaxis strategies. Results Thirteen independent studies comprising up to 1549 individuals were included. Compared with single dose before anesthesia, preoperative prophylactic antibiotics significantly reduced postoperative sepsis (OR 0.31, 95% CI 0.20–0.50; P
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