Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer
This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeco
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Series Editors Daan J. A. Crommelin Robert A. Lipper
The AAPS Advances in the Pharmaceutical Sciences Series, published in partnership with the American Association of Pharmaceutical Scientists, is designed to deliver well written volumes authored by opinion leaders and authoritarians from around the globe, addressing innovations in drug research and development, and best practice for scientists and industry professionals in the pharma and biotech industries. More information about this series at http://www.springer.com/series/8825
Jeffrey Wang • Wei-Chiang Shen • Jennica L. Zaro Editors
Antibody-Drug Conjugates The 21st Century Magic Bullets for Cancer
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Editors Jeffrey Wang Western University of Health Sciences Department of Pharmaceutical Sciences Pomona California USA Wei-Chiang Shen University of Southern California Department of Pharmacology and Pharmaceutical Sciences Los Angeles California USA
Jennica L. Zaro University of Southern California Department of Pharmacology and Pharmaceutical Sciences Los Angeles California USA
ISSN 2210-7371 ISSN 2210-738X (electronic) ISBN 978-3-319-13080-4 ISBN 978-3-319-13081-1 (eBook) DOI 10.1007/978-3-319-13081-1 Library of Congress Control Number: 2014956765 Springer Cham Heidelberg New York Dordrecht London © American Association of Pharmaceutical Scientists 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I Introduction 1 Antibody-Drug Conjugates: A Historical Review����������������������������������� 3 Wei-Chiang Shen Part II The ADC Construct 2 Payloads of Antibody-Drug Conjugates�������������������������������������������������� 11 Chalet Tan 3 Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy������������������������������������������������������������������������������������ 23 Michael Ritchie, Laird Bloom, Gregory Carven and Puja Sapra 4 Linker
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