Antimicrobial Properties and Application of Polysaccharides and Their Derivatives
- PDF / 1,300,342 Bytes
- 14 Pages / 595.35 x 842 pts (A4) Page_size
- 25 Downloads / 278 Views
REVIEW
POLYMER SCIENCE
https://doi.org/10.1007/s10118-021-2506-2 Chinese J. Polym. Sci.
Antimicrobial Properties and Application of Polysaccharides and Their Derivatives Gui-Xue Xiaa†, Yue-Ming Wub†, Yu-Fang Bib, Kang Chenb, Wei-Wei Zhangb, Shi-Qi Liub, Wen-Jing Zhangb, and Run-Hui Liua,b* a State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China b Frontiers
Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory of Specially Functional Polymeric Materials and Related Technology (ECUST) Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
Abstract With the quick emergence of antibiotic resistance and multi-drug resistant microbes, more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge. Polysaccharides, as one of the major classes of biopolymers, were explored for their antimicrobial properties and applications, owing to their easy accessibility, biocompatibility and easy modification. Polysaccharides and their derivatives have variable demonstrations and applications as antimicrobial agents and antimicrobial biomaterials. A variety of polysaccharides, such as chitosan, dextran, hyaluronic acid, cellulose, other plant/animal-derived polysaccharides and their derivatives have been explored for antimicrobial applications. We expect that this review can summarize the important progress of this field and inspire new concepts, which will contribute to the development of novel antimicrobial agents in combating antibiotic resistance and drug-resistant antimicrobial infections. Keywords Antimicrobial; Drug resistance; Polysaccharides; Polysaccharide derivatives; Chitosan Citation: Xia, G. X.; Wu, Y. M.; Bi, Y. F.; Chen, K.; Zhang, W. W.; Liu, S. Q.; Zhang, W. J.; Liu, R. H. Antimicrobial properties and application of polysaccharides and their derivatives. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-021-2506-2
INTRODUCTION Microbial infection is a common community and nosocomial acquired disease that has been a global challenge and seriously threatens the health of human life.[1] Although anti-microbial treatment has made great progress in the past century, infectious diseases are still one of the three leading causes of death in the world according to the report of the International Health Organization.[2] In recent years, multidrug resistant microbial infections have been increasingly serious problems, especially with drain of the antibiotic pipeline.[3] As reported, the global death toll caused by drug-resistant bacterial infections will increase from 7×105 in 2015 to 10×107 in 2050, if without effective action and strategy.[4] Therefore, it is in great need to develop novel antimicrobial agents for variable applications. There are many glycoconjugates or glycocalix that cover the surfaces of mammalian cells. In the process of microbial infection, pathogens us
Data Loading...
