Antimicrobial hydrogels with controllable mechanical properties for biomedical application
- PDF / 1,082,007 Bytes
- 11 Pages / 584.957 x 782.986 pts Page_size
- 104 Downloads / 207 Views
FOCUS ISSUE
(NANO)MATERIALS FOR BIOMEDICAL APPLICATIONS
Antimicrobial hydrogels with controllable mechanical properties for biomedical application Si-Hao Chen1,2, Zhi Li1,2, Zu-Lan Liu1,2, Lan Cheng1,2,3, Xiao-Ling Tong1,3, Fang-Yin Dai1,2,3,a) 1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Textile and Garment, Southwest University, Chongqing 400715, China 3 Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Biotechnology, Southwest University, Chongqing 400715, China a) Address all correspondence to this author. e-mail: [email protected] 2
Received: 2 December 2018; accepted: 11 February 2019
The antibacterial hydrogels can be widely used in the biomedical area owing to their excellent properties. The main limitation of antibacterial hydrogels is their poor mechanical strength. In this study, the novel hydrogels were fabricated with a mixture of silk fibroin (SF), chitosan (CH), agarose (AG), and silver nanoparticles (SNPs) via facile reaction condition without inorganic substances. The mechanical property of these fabricated hydrogels can be modulated by the concentration of SF or AG. The rheological studies demonstrated enhanced elasticity of CH-doped hydrogels. Because of the presence of CH and Ag in hydrogels, the antimicrobial property against gram-positive and gram-negative bacteria was exhibited. Cytocompatibility test proved the very low toxic nature of the hydrogels. In addition, these composite hydrogels have a smaller porosity, higher swelling ratio, and good compatibility, indicating their great potential for biomedical application.
Introduction Skin, the tissue wrapping around muscle, is the largest organ in the human body with the function of protecting tissues and organs from physical, mechanical, chemical, and pathogenic injuries [1]. Skin injuries may cause tissue necrotization and hurt blood vessels, which will affect humans’ health, even lives [2]. Cuticular wounds destroy the integrity of skin and their percolate is filled with abundant body fluid, making them more prone to bacterial infection [3]. A bacterial infection will delay wound healing and induce a scar. In recent years, many researches reveal that wound healing is faster in a humid environment than in a dry condition [4], since the suppression of cytoactive level could transform wounds into scab in a dry condition which will delay wound healing [5]. The articular cartilage is central to some pandemics such as osteoarthritis, playing an important biomechanical role as a load-bearing tissue, reducing joint friction. Unfortunately, this avascular, aneural, and alymphatic dense connective tissue is structurally predisposed to low self-regeneration capacity [6]. To solve
ª Materials Research Society 2019
these problems, various materials have been developed for preventing bacterial infection and accelerating the wound healing, including foam, membrane,
Data Loading...
