Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones
This monograph gives an excellent review of the issue of antimicrobial prophylaxis in urol ogy and the use of the new fluoroquinolones in urology. The development of the fluoro quinolones has had a profound effect in urology, specifically because of the
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Thomas C. Gasser
Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones
Thomas Gasser, M.D. Urologic Clinics Department of Surgery University Hospital (Kantonsspital) 4031 Basel Switzerland
Die Deutsche Bibliothek - CIP-Einheitsaufnahme Gasser, Thomas C.: Antimicrobial prophylaxis in urology with special reference to the new quinolones I Thomas C. Gasser. - Darmstadt: Steinkopff, 1992 (Fortschritte der Urologie und Nephrologie) ISBN-13:978-3-7985-0942-9 e-ISBN-13:978-3-642-85422-4 DOl: 10.1007/978-3-642-85422-4 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, as amended on June 24,1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. Copyright ~ 1992 by Dr. Dietrich SteinkopffVerlag & Co. KG, Darmstadt Medical Editorial: Sabine Miiller- English Editor: James C. Willis - Production: Heinz J. Schafer
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: Typoservice, 6146 Alsbach Printed on acid-free paper
Preface
This monograph gives an excellent review of the issue of antimicrobial prophylaxis in urology and the use of the new fluoroquinolones in urology. The development of the fluoroquinolones has had a profound effect in urology, specifically because of the unique pharmacokinetics of the fluoroquinolones with their two or more pK values, making concentration of these compounds possible in the prostate. Their wide spectra against infecting organisms causing infections in the urinary tract have also made them popular and almost ideal in the treatment of urinary tract infections. This thesis summarizes in an concise way and brings up to date practically all our knowledge concerning the use of fluoroquinolones in urology. The chapter on antimicrobial prophylaxis covers our present knowledge completely, especially concerning the use of these drugs in antimicrobial prophylaxis in transurethral surgery.
September 1992
PaulO. Madsen Madison, Wisconsin, USA
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Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
V
I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
1.1. Author's Publications Referred to in Text . . . . . . . . . . . . . . . . . . . . . . 1.2. Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3. Problems of Antimicrobial Prophylaxis in Urology . . . . . . . . . . . . . . . .
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D. General
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