Antioxidant and Antiradical Properties of Resveratrol and Its Antistress Activity
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ICAL PHYSICS OF BIOLOGICAL PROCESSES
Antioxidant and Antiradical Properties of Resveratrol and Its Antistress Activity I. V. Zhigachevaa, *, V. I. Binyukova, I. F. Rusinab, E. M. Mil’a, and I. P. Generozovac aEmanuel
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia c Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, 127276 Russia *e-mail: [email protected]
bSemenov
Received April 12, 2019; revised May 18, 2019; accepted May 20, 2019
Abstract—The antiradical properties and biological activity of natural polyphenol—resveratrol—are studied. The chemiluminescence method recorded high values of the antiradical activity of this drug. Using the model system, it is shown that the drug in the concentration range of 10–5 to 10–12 M prevented the activation of lipid peroxidation (LPO) in the mitochondrial membranes of pea seedlings, which could indicate the presence of antistress properties in this preparation, which are studied under conditions of water deficiency, which causes LPO and leads to mitochondrial swelling. Resveratrol seed treatment (3 × 10–5 M) under these conditions leads to a decrease in the number of swollen mitochondria and the appearance of small mitochondria, which, perhaps, is a sign of the activation of mitochondrial biogenesis. Resveratrol, which prevents LPO, helps maintain the functional state of mitochondria and activates the energy metabolism by increasing their number, which is reflected in the physiological parameters: the drug prevents a decrease in the growth rate of pea seedlings in conditions of water deficiency. Based on the data obtained, it is assumed that the drug has antistress properties in the concentration range in which it exhibits an antioxidant effect. Keywords: resveratrol, antioxidants, active oxygen species, free radical oxidation, lipid peroxidation, mitochondria DOI: 10.1134/S1990793120040120
INTRODUCTION Resveratrol (RV)—trans-3,4,5-trihydroxystilbene—is a natural polyphenol with a stilbene structure. Its chemical structure was characterized in 1940, when it was isolated from the root of Veratrum grandiflorum [1]. Currently, it is found in more than 72 plant species [2]. Its content in plants varies and increases in response to biotic and abiotic stresses [3, 4]. Plants containing resveratrol have been used effectively in folk medicine for more than 2000 years. However, the study of its biological activity began only after the publication of the results of studies by Baur and Sinclair [5]. Then it turned out that resveratrol significantly prolongs the life of the yeast Saccharomyces cerevisiae and the fruit flies. A number of studies have shown the presence of antimicrobial, cardioprotective, and antitumor activity in resveratrol [6–8]. It is known that it also inhibits the proliferation of various tumor cells through the caspase-8-dependent (receptor-mediated) or caspase9-dependent (mitochondrial) pathway [9]. D
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