A compound plant extract and its antibacterial and antioxidant properties in vitro and in vivo
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ORIGINAL ARTICLE
A compound plant extract and its antibacterial and antioxidant properties in vitro and in vivo Xin Tao1 · Yuqing Sun1 · Xiaoming Men1 · Ziwei Xu1 Received: 7 July 2020 / Accepted: 28 October 2020 / Published online: 13 November 2020 © King Abdulaziz City for Science and Technology 2020
Abstract The present study was conducted to prepare a compound plant extract as a candidate animal feed additive. Firstly, Evodia rutaecarpa (ER), Schisandra sphenanthera (SS), Punica granatum (PG) and Artemisia argyi (AA) were screened out from 17 plants as materials of candidate compound plant extracts by measuring the antibacterial rate on Escherichia coli and Salmonella paratyphoid, and the scavenging capability on 2,2 diphenyl-1-picrylhydrazine radical in vitro. Secondly, proportions of the four materials were optimized with an L9 (43) orthogonal experiment. By range analysis of experimental results, two compound extracts (named as F1 and F2) with the strongest antibacterial and antioxidant functions were obtained. The ratio of ER: SS: PG: AA is 9:9:1:3 in F1 and 9:9:9:3 in F2, respectively. Finally, the effects of F1 and F2 on security and efficacy in vivo were evaluated. In healthy mice, F1 had no significant effects (p > 0.05) on all blood parameters and viscera indices, and at 1000 mg/kg bw dose significantly increased (p
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