Applied Statistics in Biomedicine and Clinical Trials Design Selecte
This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The six sections cover Bayesian methods in biomedical research; Diagnostic medicine and classificatio
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The ICSA Book Series in Statistics showcases research from the International Chinese Statistical Association that has an international reach. It publishes books in statistical theory, applications, and statistical education. All books are associated with the ICSA or are authored by invited contributors. Books may be monographs, edited volumes, textbooks and proceedings. More information about this series at http://www.springer.com/series/13402
Zhen Chen • Aiyi Liu • Yongming Qu Larry Tang • Naitee Ting • Yi Tsong Editors
Applied Statistics in Biomedicine and Clinical Trials Design Selected Papers from 2013 ICSA/ISBS Joint Statistical Meetings
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Editors Zhen Chen National Institutes of Health Rockville, Maryland, USA
Larry Tang George Mason University Fairfax, Virginia, USA
Aiyi Liu National Institutes of Health Rockville, Maryland, USA
Naitee Ting Boehringer-Ingelheim Ridgefield, Connecticut, USA
Yongming Qu Lilly Corporation Center Indianapolis, Indiana, USA
Yi Tsong Food and Drug Administration Silver Spring, Maryland, USA
ISSN 2199-0980 ICSA Book Series in Statistics ISBN 978-3-319-12693-7 DOI 10.1007/978-3-319-12694-4
ISSN 2199-0999 (electronic) ISBN 978-3-319-12694-4 (eBook)
Library of Congress Control Number: 2015934689 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This symposium volume is dedicated to Dr. Gang Zheng for his passion in statistics
Preface
The 22nd annual Applied Statistics Symposium of the International Chinese Statistical Association (ICSA), jointly with the International Society for Biopharmaceutical Statistics (ISBS) was successfully held from June 9 to June 12, 2013 at the Bethesda North Marriott Hotel & Conference Center, Bethesda, Maryland, USA. The theme of this joint conference was “Globalization of Statistical Application
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