Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBO
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBOUND study Jeong Mi Kim1, Sang Soo Kim1*† , In Joo Kim1*†, Jong Ho Kim1,8, Bo Hyun Kim1, Mi Kyung Kim2, Soon Hee Lee3, Chang Won Lee4, Min Chul Kim5, Jun Hyeob Ahn6 and Jinmi Kim7 for the Relationship between Cardiovascular disease and Brachial-ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes (REBOUND) Study Group
Abstract Background: This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker of arterial stiffness for the prediction of all-cause and cause-specific mortality in patients with type 2 diabetes. Methods: This multicenter prospective observational study analyzed 2308 patients with type 2 diabetes between 2008 and 2018. The patients were categorized according to the quartiles of baPWV. Cause of mortality was determined using death certificates and patient clinical records. We estimated proportional mortality rates from all causes, cardiovascular, cancer, and other causes among adults with diabetic status according to their baPWV. Cox regression models were used to estimate hazard ratios (HRs). Results: There were 199 deaths (8.6%) in the study population during a median follow-up duration of 8.6 years. When baPWV was assessed as quartiles, a significantly higher risk of all-cause mortality (HR = 5.39, P
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