Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non‑reduced or reduced left ventricular ejection fraction Takahiro Abe1, Takashi Yokota1* , Arata Fukushima1, Naoya Kakutani1, Takashi Katayama1, Ryosuke Shirakawa1, Satoshi Maekawa1, Hideo Nambu1, Yoshikuni Obata1, Katsuma Yamanashi1, Ippei Nakano1, Shingo Takada1, Isao Yokota2, Koichi Okita3, Shintaro Kinugawa1 and Toshihisa Anzai1
Abstract Background: Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. Here, we tested the hypothesis that the coexistence of T2DM lowers CHF patients’ peak aerobic capacity. Methods: We retrospectively analyzed the cases of 275 Japanese CHF patients with non-reduced ejection fraction (left ventricular ejection fraction [LVEF] ≥ 40%) or reduced EF (LVEF
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