Assessment of SPECT-CT fusion images and semi-quantitative evaluation using SUV in 123 I-IMP SPECT in patients with chor
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ORIGINAL ARTICLE
Assessment of SPECT‑CT fusion images and semi‑quantitative evaluation using SUV in 123I‑IMP SPECT in patients with choroidal melanoma Kana Yamazaki1,2 · Ryuichi Nishii1 · Takamasa Maeda3 · Hirokazu Makishima4 · Goro Kasuya4 · Tachen Chang4 · Kentaro Tamura1 · Masaru Wakatsuki4 · Hiroshi Tsuji4 · Koji Murakami2 · Tatsuya Higashi1 Received: 23 July 2020 / Accepted: 27 August 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objectives The aim of this study was to assess the diagnostic ability of N-isopropyl-p-[I-123] iodoamphetamine (IMP) SPECT semi-quantitative evaluation based on the standardized uptake value (SUV) in patients with choroidal melanoma. The secondary aim was to investigate the 6-h IMP SPECT imaging in comparison with 24-h imaging. Methods Twenty-five patients (14 males and 11 females, mean age of 59.2-year-old) were analyzed in this retrospective study. Patients underwent 24-h IMP SPECT imaging with a gamma camera after intravenous injection of IMP. Twelve of 25 patients underwent 6-h SPECT imaging in addition to the 24-h imaging. All acquired SPECT images were fused with CT images using an image-analysis software. To assess the utility of semi-quantitative evaluation method, we introduced an image evaluation method using SUVmax comparing with conventional count-based uptake index (UI) evaluation of the lesion. Volumes-of-interest (VOIs) for SUVmax and regions-of-interest (ROIs) for UI were drawn referring to the SPECT-CT fusion image. Then the relationship between the 6- and 24-h images was examined both in SUV and UI evaluation. Furthermore, the relationship between the size category classification (SCC) by UICC/AJCC: 1–4 scales and each semi-quantitative value using SUVmax and UI was also assessed. Results SUVmax of the tumor was significantly higher than that of the normal side; 2.37 ± 0.88 and 1.77 ± 0.39 (P
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