Association between maternal alcohol use during pregnancy and gestational diabetes mellitus: a meta-analysis
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REVIEW ARTICLE
Association between maternal alcohol use during pregnancy and gestational diabetes mellitus: a meta-analysis Sai-Ling Hu 1 & Bi-Tong He 1 & Ren-Jie Zhang 2 Received: 9 June 2020 / Accepted: 25 September 2020 # Research Society for Study of Diabetes in India 2020
Abstract Purpose Maternal alcohol use and gestational diabetes mellitus (GDM) have been serious public health issues worldwide. This study aimed to investigate the association between maternal alcohol use during pregnancy and risk of GDM via a meta-analysis. Material and methods PubMed, ScienceDirect, and Cochrane Library databases were systematically searched up to March 25, 2020. Observational studies on associations between maternal alcohol use during pregnancy and risk of GDM were retrieved. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) for with versus without alcohol use during pregnancy were calculated using a random-effect model. The publication bias was assessed by Begg’s rank correlation test. Results A total of 7 observational studies (185,235 participants, including 8368 GDM cases) were included in this meta-analysis. Compared with women without any use of alcohol during pregnancy, the pooled OR for women with alcohol use was 0.74 (95% CI 0.50–1.10). In subgroup analysis, the pooled OR was 0.79 (95% CI 0.60–1.05) and 0.71 (95% CI 0.28–1.80), respectively, for individual study with and without adjusting for body mass index. Conclusions Our findings suggest that there is no discernible association between maternal alcohol use during pregnancy and risk of GDM. However, given other possible pregnancy complications and adverse birth outcomes induced by alcohol use, women who have been pregnant and are planning to become pregnant should quit drinking. Keywords Alcohol . Gestational diabetes mellitus . Meta-analysis . Pregnancy . Risk factor
Introduction Maternal alcohol use during pregnancy has been and remains a serious public health problem worldwide. Based on results of a recent systematic review study, 9.8% of women reported alcohol use during pregnancy globally and the highest prevalence was seen in European region (25.2%) [1]. Specific to countries, data from the 2015–2017 Behavioral Risk Factor Surveillance System (BRFSS) showed that 11.5% of the US
* Ren-Jie Zhang [email protected] Sai-Ling Hu [email protected] Bi-Tong He [email protected] 1
Lishui Municipal Center Hospital, 289 Kuocang Road, Lishui 323000, China
2
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, China
pregnant women aged 18–44 years were current drinkers [2]. Consisted of 7905 women, a multinational European study suggested that the prevalence of alcohol consumption during pregnancy in UK and Russia was 28.5% and 26.5%, respectively [3]. Besides, in Spain, although alcohol consumption among expectant mothers has declined, up to 2014, 5.4% of women still used alcohol during pregnancy [4]. Alcohol use during pregnancy is reported to be associated with a wide range of pregnancy complicat
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