Association study of a single nucleotide polymorphism in brain cytoplasmic 200 long-noncoding RNA and psychiatric disord
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ORIGINAL ARTICLE
Association study of a single nucleotide polymorphism in brain cytoplasmic 200 long-noncoding RNA and psychiatric disorders Mir Salar Kahaei 1 & Soudeh Ghafouri-Fard 1 & Amir Namvar 1 & Mir Davood Omrani 1 & Arezou Sayad 1 & Mohammad Taheri 2 Received: 19 February 2020 / Accepted: 19 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The Brain cytoplasmic 200 RNA (BC200 RNA) is neuron-specific lncRNA with putative roles in normal aging and in the pathogenesis of Alzheimer’s disease. Its role in the neuron plasticity has also been documented. In the current study, we genotyped a single nucleotide polymorphism (SNP) within this lncRNA (rs4404327) in a population of Iranian patients with diverse neuropsychiatric conditions including substance addiction (n = 315), attention deficit hyperactive disorder (ADHD) (n = 53), bipolar 1 (BP1) (n = 131), bipolar 2 (BP2) (n = 68), major depressive disorder (MDD) (n = 56) and schizophrenia (SCZ) (n = 177) as well as age−/ sex-matched healthy controls. This SNP was associated with ADHD in co-dominant model (C/T vs. C/C) (OR (95% CI) = 3.7 (1.96–10), P value = 0.000193), dominant model (C/T + T/T vs. C/C) (OR (95% CI) = 4.43(2.02–9.72), P value = 1.37E-04) and multiplicative model (C vs. T) (OR (95% CI) = 3.20(1.64–6.25), P value = 4.316269E-04). Moreover, this SNP was associated with risk of BP1 in dominant model (OR (95% CI) = 1.67(1.08–2.62), P value = 0.02) and multiplicative model (OR (95% CI) = 1.51 (1.04–2.21), P value = 0.028). After correction for multiple comparisons (6 cohorts × 4 models), associations remained significant in ADHD but not in BP1. No other significant association was detected. The current project showed association between a certain SNP within BC200 RNA and ADHD. Further studies are required to assess these associations in larger cohorts of patients and find the underlying mechanism for this observation. Keywords Brain cytoplasmic 200 RNA . rs4404327 . Substance abuse . ADHD . Bipolar disorder . Major depressive disorder, schizophrenia
Introduction Long non-coding RNAs (lncRNAs) are a group of heterogeneous transcripts with sizes greater than 200 nucleotides. Mir Salar Kahaei and Soudeh Ghafouri-Fard contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11011-020-00582-7) contains supplementary material, which is available to authorized users. * Arezou Sayad [email protected] * Mohammad Taheri [email protected] 1
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
These transcripts have diverse roles in physiological functions (Marchese et al., 2017). While these transcripts don not usually have protein coding aptitude, their expression is finely regulated in a spatiotemporal-dependent manner (Cao et al., 2018). LncRNAs can modulate transcription of genes through changing chrom
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