Associations of histological and molecular alterations with invasion of the corpus callosum in gliomas
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ORIGINAL ARTICLE - TUMOR - GLIOMA
Associations of histological and molecular alterations with invasion of the corpus callosum in gliomas Shaoping Shen 1 & Shiyu Feng 1 & Hailong Liu 1 & Jingjing Jiang 2 & Xinguang Yu 1 Received: 10 February 2020 / Accepted: 25 April 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Background Glioma invading the corpus callosum (CC) accounts for approximately 14% of gliomas and is thought to be more aggressive. However, there is still a lack of studies on the pathogenesis and molecular features of this condition. Here, we examined the occurrence association of CC invasion with respect to patients’ clinical, pathological, and genetic characteristics. Methods First, a cohort of 331 patients was included, with 86 cases (26%) that were diagnosed with invasion glioma. They were all analyzed for basic clinical and pathological characteristics and four routinely tested glioma molecular markers. Second, 29 pairs of patients who underwent deep sequencing of 68 glioma molecular alterations were selected from both groups for in-depth analysis. Results The results of the first part showed that there was no difference between the two groups in terms of the basic factors in univariate analysis, while in multivariate logistic analysis, WHO grade was the risk factor for CC invasion (p = 0.001). The results of the second part showed that the paired groups had different genetic expression profiles, which highlighted glioma invading the CC as a distinct biological entity. PDGFRA mutation (PDGFRAmut) was present in 9 patients with invasive gliomas (31%), but only in one case (3.4%) in the control group (OR 17.331; 95% CI 1.987–151.156). Conclusion Our data revealed the clinical, pathological, and genetic characteristics of glioma invading the CC and showed that it may be associated with glioma WHO grade and PDGFRAmut, but not other factors. Thus, the risk signaling pathway may offer potential therapeutic targets for this disease. Keywords Corpus callosum . Glioma . Glioma molecular alterations . Butterfly Gliomas . Genetic characteristics . PDGFRA
Introduction Glioma accounts for almost 80% of primary malignant brain tumors [12, 17]. Although some targeted therapies such as targeting BRAF [18], EGFR [20], and NF1 [22] have been This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Shaoping Shen and Shiyu Feng are co-first author. This article is part of the Topical Collection on Tumor – Glioma. * Xinguang Yu [email protected] 1
Department of Neurosurgery, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
2
Clinical Specimen Bank, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China
adopted for clinical trials, maximal surgical resection is still the standard first-line treatment for glioma. In general, the extent of resection (EOR) is one of the most important independent fact
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