Associations of serum iron and ferritin with hyperuricemia and serum uric acid
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ORIGINAL ARTICLE
Associations of serum iron and ferritin with hyperuricemia and serum uric acid Yilun Wang 1 & Zidan Yang 2 & Jing Wu 2 & Dongxing Xie 1 & Tuo Yang 3 & Hui Li 1 & Yilin Xiong 1 Received: 6 December 2019 / Revised: 13 April 2020 / Accepted: 11 May 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objectives To assess the serum iron and ferritin levels in relation to the prevalence of hyperuricemia (HU) and the serum uric acid (SUA) level. Methods Serum iron and ferritin concentrations were detected by Ferene method and chemiluminescence method, respectively. SUA level was detected by uricase-PAP method. HU was defined as SUA ≥ 416 μmol/L for male and ≥ 357 μmol/L for female. Multivariable-adjusted logistic regressions were constructed to investigate the associations between serum iron/ferritin levels and prevalence of HU. Pearson correlation analysis and multivariable linear regression were performed to examine the correlations between serum iron/ferritin levels and SUA level. Results A total of 2824 subjects (mean age 52.2 ± 7.2) were included. The overall prevalence of HU was 17.3%. Compared with the lowest quartile, the multivariable-adjusted odds ratios (OR) and its 95% confidence interval (CI) of HU were 1.33 (95%CI 0.97–1.82), 1.17 (95%CI 0.85–1.60), and 1.56 (95%CI 1.14–2.13) in the second, third, and fourth quartiles of serum iron, respectively (P for trend = 0.012), and were 1.29 (95%CI 0.89–1.88) in the second, 2.13 (95%CI 1.47–3.07) in the third, and 2.25 (95%CI 1.54–3.29) in the fourth quartile of serum ferritin (P for trend < 0.001). Pearson correlation coefficient indicated a weak positive correlation between serum iron (r = 0.2, P < 0.001) and ferritin (r = 0.3, P < 0.001) levels and SUA. Such positive correlations were further confirmed by multiple linear regression (serum iron: standardized β = 0.059, P < 0.001; serum ferritin: standardized β = 0.061, P = 0.001). Conclusions Both serum iron and ferritin showed a positive correlation with the prevalence of HU, and a weak positive correlation with SUA level. Key Points • Subjects with higher levels of serum iron or ferritin had higher prevalence of HU. • There was a weak positive correlation between serum iron/ferritin levels and SUA level.
Keywords Cross-sectional study . Ferritin . Hyperuricemia . Iron . Uric acid
Introduction
* Hui Li [email protected] * Yilin Xiong [email protected] 1
Department of Orthopaedics, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha 410008, Hunan, China
2
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China
3
Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
Serum uric acid (SUA), a terminal metabolite of purine compound, is known as a powerful endogenous antioxidant that can protect cells from oxidative stress–induced damage [1]. However, an abnormal increase in SUA concentration may cause hyperuricemia (HU) [2
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