Attenuating properties of Rubus fruticosus L. on oxidative damage and inflammatory response following streptozotocin-ind
- PDF / 440,452 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 12 Downloads / 160 Views
RESEARCH ARTICLE
Attenuating properties of Rubus fruticosus L. on oxidative damage and inflammatory response following streptozotocin-induced diabetes in the male Wistar rats Naser Mirazi 1 & Abdolkarim Hosseini 2 Received: 23 May 2020 / Revised: 10 September 2020 / Accepted: 28 September 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose Diabetes mellitus is a prevalent metabolic disorder that entails numerous complications in various organs. In current era, different types of diseases are being treated by the applications of herbs. The present study is aimed at investigating the antiinflammatory and antioxidant effects of the Rubus fruticosus hydroethanolic extracts (RFHE) in the streptozotocin (STZ)induced diabetic rats. Methods At this experimental research, male Wistar rats with the weight of 220 ± 20 g, were categorized randomly into five groups of vehicles as control, STZ (60 mg kg− 1 of body weight, intraperitoneally (i.p.)) and RFHE (50, 100 and 200 mg kg− 1, i.p.). In the last stage (end of week 4) of the experiment, after being euthanized, the blood samples of the rats were collected for measuring malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS) as well as inflammatory markers like tumor necrosis factor (TNF)-α, interleukin (IL)-6 and C-reactive protein (CRP). Results Data from this study was revealed that diabetes causes oxidative damage and consequently the serum level of inflammatory markers rises. RFHE was shown to be significantly correlated with lowering the level of MDA, TNF-α, IL-6 and CRP of diabetic rats. Moreover, RFHE significantly elevated the GSH and TAS serum levels in diabetic rats when compared with STZ group. Conclusions RFHE might have anti-diabetic properties; this outcome may be mediated by high antioxidant and antiinflammatory effects. Keywords Rubus fruticosus . Antioxidant activity . Diabetes . Streptozotocin . Inflammation
Introduction Diabetes mellitus (DM) is amongst the most rampant metabolic disorders that involves many ramifications in various organs [1]. Diabetes involves hyperglycemia and impaired metabolism of carbohydrates, proteins and fats. It is very prevalent and costly chronic diseases throughout the world which its rate of prevalence is exponentially growing due to the
* Naser Mirazi [email protected] 1
Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran
2
Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
changes in lifestyles and improvements in the health and therapeutic status of communities, which have led to increased survival rate [2]. Studies suggest that there is a significant correlation between diabetes and age, body mass index (BMI), and family history as well as gender [3]. Statistics in 1997 demonstrated that around 124 million patients were diagnosed with the disease [4]. Some of the factors that increase the risk of diabetes include: low control of blood glucose, elongated duration or even
Data Loading...
