Autoimmune Hepatitis A Guide for Practicing Clinicians
With a focus on practical patient related issues, Autoimmune Hepatitis: A Guide for Practicing Clinicians serves as a useful practical, and much needed, resource for all those physicians presented with managing patients diagnosed with autoimmune hepatitis
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Series Editor George Y. Wu University of Connecticut Health Center, Farmington, CT, USA
For further volumes: http://www.springer.com/series/7672
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Gideon M. Hirschfield
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E. Jenny Heathcote
Editors
Autoimmune Hepatitis A Guide for Practicing Clinicians
Editors Gideon M. Hirschfield, MB, BChir, MRCP, PhD Department of Medicine Toronto Western Hospital, University Health Network, University of Toronto Ontario, Canada Centre for Liver Research Institute of Biomedical Research University of Birmingham, UK [email protected]
E. Jenny Heathcote, MD, FRCP, FRCP(C) Department of Medicine Toronto Western Hospital University Health Network University of Toronto Ontario, Canada [email protected]
ISBN 978-1-60761-568-2 e-ISBN 978-1-60761-569-9 DOI 10.1007/978-1-60761-569-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939088 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Autoimmune hepatitis is a relatively rare chronic inflammatory disease of the liver, which is seen in adults and children, women and men, and across the world. It remains somewhat of a curiosity given the lack of specific diagnostic tests. Nevertheless, a pattern of clinical and laboratory presentation, coupled with an absence of alternative etiologies, remains a reliable way for clinicians to identify patients with this disease. Untreated mortality is high from severe disease, but fortunately immunosuppression with steroids and azathioprine in particular is very effective, and the outcomes for patients are now excellent, given appropriate diagnosis and prompt treatment. Nevertheless, with the recognized side effects of treatment it remains important for clinicians to be confident in their diagnosis, and to have clear strategies for how they manage their patients over the long term. With this in m
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