Baclofen overdose
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Decreased consciousness and haemodynamic instability treated with soya oil emulsion: case report A "middle-aged" woman [age not stated] developed severe baclofen toxicity, with decreased consciousness and haemodynamic instability, after an overdose of baclofen. The woman ingested an unknown quantity of baclofen tablets and was taken to hospital. She was transported by paramedics to a hospital; her Glasgow Coma Scale (GCS) score deteriorated en route [time to reaction onset not stated]. Upon her arrival at the emergency department, her GSC was 8, HR was 65, BP was 101/60 and her RR was 16. Her GCS and BP continued to deteriorate over the next hour. The woman received a fluid bolus, but her condition did not improve. She was intubated, and a 20% solution of soya oil emulsion was administered as a bolus, at a dosage of 1.5 cc/kg. Her BP rose to 89/57 within 30 minutes; she subsequently received an infusion of soya oil emulsion 0.25 cc/kg/min for 30 minutes, and her BP continued to normalise. Her haemodynamic status stabilised within 2 hours of receiving the soya oil emulsion, and she was extubated and discharged the following day. Author comment: "This case demonstrated the first reported use of lipid emulsion therapy in the treatment of haemodynamic instability due to a baclofen overdose." Jelic T, et al. Novel use of intralipid in the treatment of severe baclofen toxicity. 803078678 Clinical Toxicology 50: 584-585 abstr. 25, No. 7, Aug 2012. - Canada
0114-9954/10/1424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 20 Oct 2012 No. 1424
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