Bacterial Virulence Factors and Rho GTPases
Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The first role of these virulence factors is to loosen the host defenses against microo
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
P. Boquet and E. Lemichez (Eds.)
Bacterial Virulence Factors and Rho GTPases With 28 Figures and 4 Tables
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Professor Dr. Patrice Boquet Professor Dr. Emmanuel Lemichez INSERM U627, IFR 50 Faculty of Medicine 28, Avenue de Valombrose Nice France e-mail: [email protected], [email protected]
Cover illustration by Pr Pierre Gounon The book cover shows, by scanning electronic microscopy, a Shigella invading a HeLa cells by a process named “trigger phagocytosis”. This process requires the activation of The Rac1 and Cdc42 Rho GTPases by Shigella virulence factors. (By courtesy of Pr Pierre Gounon, Centre de Microscopie de l’Université de Nice Sophia Antipolis, Nice, France.)
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN 3-540-23865-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2005 Printed in The Netherlands The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. Rolf Lange, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Michael Hübert, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper 21/3150/YL – 5 4 3 2 1 0
Preface
Pathogenic bacteria for humans and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence within their hosts. The first role of these virulence factors is to loosen the host defenses against microorganisms represented by innate and adaptative immunities. Small GTPases of the Rho subfamily have been shown to play important functions in these systems. The chapter by B.B. Finlay is thus devoted to the pre
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