Bone Morphogenetic Proteins From Laboratory to Clinical Practice
From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of sc
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Series Editor Prof. Dr. Michael J. Parnham PLiVA Research Institute Prilaz baruna Filipovica 25 10000 Zagreb Croatia
Forthcoming titles: The Hereditary Basis of Allergic Diseases, J. Holloway, S. Holgate (Editors), 2002 Anti-Inflammatory or Anti-Rheumatic Drugs, R.O. Day, D.E. Furst, P.L. van Riel (Editors), 2002 Inflammatory Processes and Cancer, D.W. Morgan, U. Forssmann, M. Nakada (Editors), 2003 Inflammation and Cardiac Diseases, G.Z. Feuerstein (Editor), 2003 (Already published titles see last page.)
Bone Morphogenetic Proteins From Laboratory to Clinical Practice
Siobodan Vukicevic Kuber 1. Sampath Editors
Springer Basel AG
Editors Slobod an Vukicevic Laboratory for Mineralized Tissues School of Medicine Salata 11 10000 Zagreb Croatia
Kuber T. Sampath Genzyme Corporation One Mountain Road Framingham, MA 01701-9322 USA
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data Bone morphogenetic proteins. From laboratory to clinical practice / Siobodan Vukicevic ; Kuber T. Sampath, ed .. - Basel ; Boston; Berlin: Birkhăuser, 2002 (Progress in inflammation research)
ISBN 978-3-0348-9446-3 ISBN 978-3-0348-8121-0 (eBook) DOI 10.1007/978-3-0348-8121-0
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use.
ISBN 978-3-0348-9446-3 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of iIIustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained.
© 2002 Springer Basel AG
Originally published by BirkhăuserVerlag in 2002 Softcover reprint of the hardcover lst edition 2002 Printed on acid-free paper produced from chlorine-free pulp. TCF ~ Cover design: Markus Etterich, Basel Cover illustration: Image of the sagital cranial section of a 17.5-day rat embryo (see page 101)
ISBN 978-3-0348-9446-3 987654321
www.birkhăuser-science.com
Contents
List of contributors
..........................................................
~i
Preface
xi
David C. Rueger Biochemistry of bone morphogenetic proteins .......... .
1
Vishwas M. Paralkar, William A. Grasser, Amy P. Baumann, Tessa A. Castleberry, Thomas A. Owen and Siobodan Vukicevic Prostate-derived factor and growth and differentiation factor-8: newly discovered members of the TGF-f3 superfamily........................... 19 alexander Korchynsky and Peter ten Dijke Bone morphogenetic protein receptors and their nuclear effectors in bone
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