Basal and longitudinal changes in serum levels of TSH in morbid obese patients experiencing failure or success of dietar
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ORIGINAL ARTICLE
Basal and longitudinal changes in serum levels of TSH in morbid obese patients experiencing failure or success of dietary treatment Laura Croce1,2,3 · Cristina Pallavicini1 · Silvia Crotti1 · Francesca Coperchini1 · Linda Minnelli2 · Flavia Magri1,2 · Luca Chiovato1,2 · Mario Rotondi1,2 Received: 15 July 2020 / Accepted: 30 September 2020 © The Author(s) 2020
Abstract Purpose The relationship between thyroid function and obesity is a widely investigated one. The impact of thyroid hormones in determining the outcome of dietary/lifestyle interventions remains to be fully elucidated. The aim of this study was to compare basal and post dietary-intervention circulating thyroid-function parameters, lipid profile and fasting-glucose in euthyroid obese patients according to a success or failure of a dietary intervention program. Methods In a retrospective longitudinal case–control study we enrolled 50 euthyroid obese patients who experienced a success in dietary intervention, as defined by a BMI reduction of at least 5% from baseline (Success Group) and 50 sex and age-matched euthyroid obese patients who experienced failure in dietary intervention as defined by either stable or increased body weight throughout the follow-up (Failure Group). Serum thyroid function parameters and metabolic profile at baseline and at the end of follow-up were collected. Results At baseline, the two groups showed similar BMI, total-cholesterol, HDL-cholesterol and fasting-blood-glucose, but patients in Success Group had a significantly higher TSH as compared with Failure Group (2.20 ± 0.97 vs 1.66 ± 0.73, respectively, p
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