BCL-2: From Translocation to Therapy
Impaired apoptosis is a critical step in the development of cancer and a major impediment to effective therapy. Bcl-2, the oncoprotein activated by chromosome translocation in human follicular lymphoma, inhibits cells from undergoing apoptosis in response
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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong
Subseries of Lecture Notes in Computer Science
Martin Vingron Limsoon Wong (Eds.)
Research in Computational Molecular Biology 12thAnnual International Conference, RECOMB 2008 Singapore, March 30 – April 2, 2008 Proceedings
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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Martin Vingron Max Planck Institute for Molecular Genetics Ihnestr. 63-73, 14195 Berlin, Germany E-mail: [email protected] Limsoon Wong National University of Singapore, School of Computing Law Link, Singapore 117590 E-mail: [email protected]
Library of Congress Control Number: 2008922908
CR Subject Classification (1998): F.2.2, F.2, E.1, G.2, H.2.8, G.3, I.2, J.3 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13
0302-9743 3-540-78838-7 Springer Berlin Heidelberg New York 978-3-540-78838-6 Springer Berlin Heidelberg New York
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12247264 06/3180 543210
Preface
This volume contains the papers presented at the 12th Annual International Conference on REsearch in COmputational Molecular Biology (RECOMB 2008) held in Singapore, March 30-April 2, 2008. The RECOMB conference series was founded in 1997 by Sorin Istrail, Pavel Pevzner and Michael Waterman. Its history is summarized in the table herein. The general development of the RECOMB conference series is guided by a Steering Committee. RECOMB 2008 was hosted by the National University of Singapore and held at the University Cultural Centre. The Conference Chair was Limsoon Wong, who was supported by a 16-member-strong Organizing Committee. Out of 193 papers submitted to RECOMB 2008, the Program Committee (PC) selected 34 papers for presentation at the conference. The PC consisted of 46 members, who could further draw on the help of subreviewers. Three PC members with possible help of the external reviewers first reviewed each paper, subsequently a Web-based discussion led to t
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