Benzodiazepines A Handbook. Basic Data, Analytical Methods, Phar
To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa rable advance in the past two decades. It is therefore not s
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Benzodiazepines A Handbook Basic Data, Analytical Methods, P~acok]neticsand
Comprehensive Literature
With 152 Figures
Springer-Verlag Berlin Heidelberg New York 1982
Dr. rer. nat Harald Schutz Diplom-Chemiker Institut fUr Rechtsmedizin der Justus Liebig-Universitiit Frankfurter StraBe 58, D-6300 Giessen
ISBN-13: 978-3-642-68428-9 DOl: 10.1007/978-3-642-68426-5
e-ISBN-13: 978-3-642-68426-5
This work is subject to copyright All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use a fee is payable to "Verwertungsgesellschafi Wort", Munich. © Springer-Verlag Heidelberg 1982 Softcover reprint of the hardcover 1st edition 1982 The use of general descriptive names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Mark Act, may accordingly be used freely by anyone.
2119/3140-543210
Preface
To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately comparable advance in the past two decades. It is therefore not surprising that the formerly dominant barbiturates and bromocarbamides have had to give way in many fields to the benzodiazepines, which now rank first (Proudfoot and Park [1828]). Closely linked with the great therapeutic importance of the benzodiazepines are analytical problems. Detection and the determination of blood levels can be necessary under therapeutic aspects, for instance in working out optimally effective levels in the treatment of epileptic conditions ("drug monitoring"), but also in connection with questions at issue in toxicology and traffic medicine. A toxicological analysis can be subdivided into the following steps: Detection (identification including screening) Determination (e. g. blood, plasma or serum levels) Interpretation of the analytical results. This book is intended as a contribution to each of these chapters: The part "Analytical Data" (pp.I-122) gives a comprehensive collection of data, e.g. general and chromatographic data (TLC, GLC) as well as spectra (UV, IR, MS) of 19 commercial preparations, 23 important metabolites and 18 hydrolysis derivatives. Information about biotransformation and the possible formation of aminobenzophenone derivatives is also given. The most important analytical methods are presented in an extensive review on pp.123-204 in order to make it possible to select the optimum method on the basis of the essential data. Another review (pp.205-244) and several diagrams facilitate the interpretation of quantitatively determined blood, plasma or serum concentrations. There is also a tremendous increase of the literature (see
