Berries and Cancer Prevention

Berries are popularly consumed worldwide as fresh, processed, and other derived forms. Research conducted over the last decade and a half has provided significant and convincing evidence to support the cancer preventive potential of these colorful fruits.

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Gary D. Stoner · Navindra P. Seeram Editors

Berries and Cancer Prevention

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Editors Gary D. Stoner, Ph.D Department of Medicine Medical College of Wisconsin Milwaukee, WI 53226, USA

Navindra P. Seeram, Ph.D Department of Biomedical and Pharmaceutical Sciences University of Rhode Island Kingston, RI 02881, USA

ISBN 978-1-4419-7553-9 e-ISBN 978-1-4419-7554-6 DOI 10.1007/978-1-4419-7554-6 Springer New York Dordrecht Heidelberg London © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

Among colorful fruits, berries and their derived products command an overwhelming and rapidly growing body of scientific data to support their ability to prevent, delay and potentially treat certain types of human cancers. Given that the worldwide incidence of cancer is rapidly increasing, intervention with foodstuffs, such as berries and berry formulations, provide an attractive strategy to cancer prevention. Like many other fruits, berries contain micro- and macronutrients such as vitamins, minerals, and fiber. However, berries also contain a multitude of plant secondary metabolites (phytochemicals) that exhibit a diverse array of chemical structures. It has become apparent that multiple berry constituents, through additive, complementary, and/or synergistic interactions, exhibit chemopreventive effects superior to any single component alone. This book provides focused and timely discussions on berries and cancer. The chapters presented here are collected from a multi-disciplinary team of international researchers. Thus, the fifteen chapters are organized into four sections. The first section consists of three chapters, examining the overall theme of berry composition, bioavailability, metabolism and biological effects. The second section examines the antioxidant effects of berry components which are presented in a single chapter. The third section, groups eight chapter