Caveolins in Cancer Pathogenesis, Prevention and Therapy
For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning “little caves” in latin) have been attributed to these complex
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Isabelle Mercier Jean-François Jasmin Michael P. Lisanti ●
Editors
Caveolins in Cancer Pathogenesis, Prevention and Therapy
Editors Isabelle Mercier Department of Stem Cell Biology & Regenerative Medicine Thomas Jefferson University Philadelphia, PA 19107, USA [email protected]
Jean-François Jasmin Department of Stem Cell Biology & Regenerative Medicine Thomas Jefferson University Philadelphia, PA 19107, USA [email protected]
Michael P. Lisanti Department of Stem Cell Biology & Regenerative Medicine Thomas Jefferson University Philadelphia, PA 19107, USA [email protected]
ISBN 978-1-4614-1000-3 e-ISBN 978-1-4614-1001-0 DOI 10.1007/978-1-4614-1001-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939408 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Caveolae, a subset of lipid rafts, are flask-shaped invaginations of the plasma membrane that play an important role in cellular signal transduction by concentrating several molecules in a confined microenvironment. This clathrin-independent pathway of endocytosis is also involved in other crucial cellular processes, ranging from cholesterol transport to pathogen uptake. Caveolin (Cav) proteins, the main structural components of caveolae, are essential for maintaining caveolar integrity, as well as regulating cell signaling through protein–protein interactions. Cav proteins are composed of three distinct members, namely Cav-1, -2 and -3. However, Cav-1 still remains the beststudied and well-characterized member. More specifically, Cav-1 has been implicated in the pathogenesis of several human diseases such as atherosclerosis, heart disease, stroke, diabetes, and cancer, the latter being the focus of this book. Most of the functional effects of Cav-1 are mediated through its scaffolding domain, which is located at amino acids 82–101. This domain recognizes a Cav binding motif found within signaling molecules, which can directly regulate their activities and downstream effects on cellular proliferation. Cav-1 primarily acts as a tumor suppressor
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