Bevacizumab
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Bevacizumab Metrorrhagia following intravitreal injection: case report A 35-year-old woman with branch retinal occlusion and disc neovascularisation received an intravitreal injection of bevacizumab 0.1mL (2.5mg). After 2 weeks, she reported metrorrhagia for 10 days, which was not associated with her menstrual cycle. Complete systemic, gynaecological and coagulopathy work-up showed no abnormalities. Her metrorrhagia was successfully treated with curettage and IM methylergometrin. Author comment: "The absence of hormonal and anatomical uterine dysfunction in our patient raises the possibility that [antivascular endothelial growth factor] inhibition by systematically absorbed bevacizumab yielded the uterine haemorrhage." Rodrigues EB, et al. Metrorrhagia after intravitreal injection of bevacizumab. Acta 801079558 Ophthalmologica Scandinavica 85: 915-916, No. 8, Dec 2007 - Brazil
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Reactions 12 Jan 2008 No. 1184
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