Biliary Disease From Science to Clinic
This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide rangin
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Biliary Disease From Science to Clinic
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Biliary Disease
Gideon Hirschfield • David Adams Evaggelia Liaskou Editors
Biliary Disease From Science to Clinic
Editors Gideon Hirschfield Centre for Liver Research NIHR Biomedical Research Unit Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom
Evaggelia Liaskou Centre for Liver Research NIHR Biomedical Research Unit Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom
David Adams Centre for Liver Research NIHR Biomedical Research Unit Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom
ISBN 978-3-319-50166-6 ISBN 978-3-319-50168-0 (eBook) DOI 10.1007/978-3-319-50168-0 Library of Congress Control Number: 2017933709 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Biliary diseases are important causes of acute and chronic liver illnesses that span all ages, both sexes, and individuals wherever they reside. Whilst our treatments remain presently limited, the biologic understanding of disease continues to improve. With insights into all facets of biliary disease from epidemiology, through genetics and environmental risk, to local tissue responses, a more detailed pathway can be mapped that helps patients and clinicians understand the challenges they encounter. In some cases diseases are restricted by age, or biliary location, in other facets disease features overlap (immune pathways, impact of the microbiome, resultant symptoms), and such similarities and distinctions have advanced therapeutic targets, such that treatment beyond the non-specific bile acid, ursodeoxycholic acid, is reaching the clinic environment. These continu
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