The Plasticity of Skeletal Muscle From Molecular Mechanism to Clinic
This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demand
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The Plasticity of Skeletal Muscle From Molecular Mechanism to Clinical Applications
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The Plasticity of Skeletal Muscle
Kunihiro Sakuma Editor
The Plasticity of Skeletal Muscle From Molecular Mechanism to Clinical Applications
123
Editor Kunihiro Sakuma Institute for Liberal Arts, Environment and Society Tokyo Institute of Technology Tokyo, Japan
ISBN 978-981-10-3291-2 ISBN 978-981-10-3292-9 (eBook) DOI 10.1007/978-981-10-3292-9 Library of Congress Control Number: 2017933679 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
In humans, skeletal muscle is the most abundant tissue in the body, comprising 40–50% of body mass and playing vital roles in locomotion, heat production during periods of cold stress, and the overall metabolism. It is essential for our quality of life to have healthy muscles. Skeletal muscle possesses a high plasticity for environmental stimulation such as neuronal, mechanical, hormonal, and/or immune factors. For example, the increase of mechanical stress induces muscle hypertrophy probably due to the upregulation of protein synthesis and of transcription in muscle-specific structural components. This book is about skeletal muscles, molecular mechanism of muscle hypertrophy [AMP-activated protein kinase (AMPK) and ribosome biogenesis], and atrophy [ubiquitin-proteasome system, autophagy, cytokine, redox regulation (nitric oxide), and transient receptor potential cation channels (TRPC)]. In particular, it is a very intriguing and current topic that changes in ribosome biogenesis and translational capacity correlate finely with changes in
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