Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell de
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REVIEW
Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways Srimanta Patra1 · Prakash Priyadarshi Praharaj1 · Debasna Pritimanjari Panigrahi1 · Biswajit Panda2 · Chandra Sekhar Bhol1 · Kewal Kumar Mahapatra1 · Soumya Ranjan Mishra1 · Bishnu Prasad Behera1 · Mrutyunjay Jena3 · Gautam Sethi4 · Shankargouda Patil5 · Samir Kumar Patra6 · Sujit Kumar Bhutia1,7 Received: 30 March 2020 / Accepted: 2 August 2020 © Springer Nature B.V. 2020
Abstract Marine invertebrates are extremely diverse, largely productive, untapped oceanic resources with chemically unique bioactive lead compound contributing a wide range of screening for the discovery of anticancer compounds. The lead compounds have unfurled an extensive array of pharmacological properties owing to the presence of polyphenols, alkaloids, terpenoids and other secondary metabolites. The antioxidant, immunomodulatory and anti-tumor activities exhibited, are possibly regulated by the apoptosis induction, scavenging of ROS and modulation of cellular signaling pathways to defy the cellular deafness during carcinogenesis. Despite the enriched bioactive compounds, the marine invertebrates are largely unexplored as identification, screening, pre-clinical and clinical assessment of lead compounds and their synthetic analogs remain a major task to be solved. In the current review, we focus on the principle strategy and underlying mechanisms deployed by the bioactive anticancer compounds derived from marine invertebrates to combat cancer with special insight into the cell death mechanism. Keywords Cancer · Marine invertebrates · Bioactive lead compounds · Reactive oxygen species (ROS) · Antioxidants
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11033-020-05709-8) contains supplementary material, which is available to authorized users. * Sujit Kumar Bhutia [email protected]; [email protected] Srimanta Patra [email protected] Prakash Priyadarshi Praharaj [email protected] Debasna Pritimanjari Panigrahi [email protected] Biswajit Panda [email protected] Chandra Sekhar Bhol [email protected] Kewal Kumar Mahapatra [email protected] Soumya Ranjan Mishra [email protected]
Gautam Sethi [email protected] Shankargouda Patil [email protected] Samir Kumar Patra [email protected] 1
Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela 769008, India
2
College of Basic Science & Humanities OUAT, Bhubaneswar 751003, India
3
PG Department of Botany, Berhampur University, Berhampur 760007, India
4
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
5
Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia
6
Epigenetics and Cancer Research Laboratory, Department of
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