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A N D

H E A L T H

Bioactive Compounds and Cancer Edited by

John A. Milner Donato F. Romagnolo

Bioactive Compounds and Cancer

Nutrition and Health Adrianne Bendich, PhD, FACN, Series Editor

For other titles published in this series, go to http://www.springer.com/series/7659

Bioactive Compounds and Cancer Edited by

John A. Milner National Cancer Institute, Health and Human Services, Rockville, MD

Donato F. Romagnolo Department of Nutritional Sciences, The University of Arizona, Tucson, AZ Forewords by

David S. Alberts, md Arizona Cancer Center, The University of Arizona, Tucson, AZ

Maria Lluria-Prevatt, phd Arizona Cancer Center, The University of Arizona, Tucson, AZ and

Scott M. Lippman, md Department of Thoracic/Head and Neck Medical Oncology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX

Editors John A. Milner Nutritional Science Research Group Division of Cancer Prevention National Institutes of Health Executive Plaza North Suite 3164 6130 Executive Boulevard Rockville MD 20892 USA [email protected]

Donato F. Romagnolo Department of Nutritional Sciences The University of Arizona Tucson AZ 85721-0038 Shantz Building USA [email protected]

Series Editor Adrianne Bendich, PhD, FACN GlaxoSmithKline Consumer Healthcare Parsippany, NJ USA

ISBN 978-1-60761-626-9 e-ISBN 978-1-60761-627-6 DOI 10.1007/978-1-60761-627-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010922882 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Series Editor Introduction

The Nutrition and Health Series of books have, as an overriding mission, to provide health professionals with texts that are considered essential because each includes (1) a synthesis of the state of the science, (2) timely, in-depth reviews by the leading researchers in their respective fields, (3) extensive, up-to-date full