Biocompatible composite of cellulose nanocrystal and hydroxyapatite with large mechanical strength
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ORIGINAL RESEARCH
Biocompatible composite of cellulose nanocrystal and hydroxyapatite with large mechanical strength Ryota Sato . Toshihiko Arita . Ryuichiro Shimada . Tomohiro Nohara . Keisuke Tabata . Kazuki Koseki . Kazuki Umemoto . Akito Masuhara
Received: 14 June 2020 / Accepted: 19 October 2020 Ó Springer Nature B.V. 2020
Abstract Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core–shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10570-020-03550-7) contains supplementary material, which is available to authorized users. R. Sato R. Shimada T. Nohara K. Tabata K. Koseki K. Umemoto A. Masuhara (&) Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan e-mail: [email protected] R. Sato e-mail: [email protected] R. Shimada e-mail: [email protected] T. Nohara e-mail: [email protected]
successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes.
K. Umemoto e-mail: [email protected] T. Arita (&) Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, 2-1-1, Aoba-ku, Sendai, Miyagi 980-8577, Japan e-mail: [email protected] A. Masuhara Department of Frontier Center for Organic Materials, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
K. Tabata e-mail: [email protected] K. Koseki e-mail: [email protected]
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Cellulose
Graphic abstract
Keywords Cellulose nanocrystal Hydroxyapatite Biomedical materials Tissue engineering materials Dental materials Sustainable development goals (SDGs) Abbreviations CNC Cellulose Nanocrystal HAp Hydroxyapatite CNC@HAp Composite of cellulose and hydroxyapatite
Introduction Nano-sized cellulose derived from the most abundant natural polysaccharides has greatly attracted attention in a wide range of modern industries as renewable and sustainable materials due to its low cost, light
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