Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineraliza
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SPECIAL ISSUE: CESB 2019 Original Research
Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineralization, cell responses and osteogenesis Qing Ye1,2,3 Ying Zhang2,4 Kun Dai2,3 Xiaofeng Chen3,5 Hannah Mae Read6 Lei Zeng2,4 Fei Hang1 ●
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Received: 2 July 2019 / Accepted: 15 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this study, porous bioglass/gelatin/alginate bone tissue engineering scaffolds were fabricated by three-dimensional printing. The compressive strength and in vitro biomineralization properties of the bioglass–gelatin–alginate scaffolds (BG/ Gel/SA scaffolds) were significantly improved with the increase of bioglass content until 30% weight percentage followed by a rapid decline in strength. In addition, the cells attach and spread on the BG/Gel/SA scaffolds surfaces represents good adhesion and biocompatibility. Furthermore, the cells (rat bone marrow mesenchymal stem cells, mBMSCs) proliferation and osteogenic differentiation on the BG/Gel/SA scaffolds were also promoted with the increase of bioglass content. Overall, the adding of bioglass in Gel/SA scaffolds promotes mechanical strength and in vitro osteogenic properties and the 30 BG scaffold (30%wt BG) has potential applications in bone tissue engineering and bone regenerative repair because of good compressive strength, biocompatibility, and in vitro osteogenesis. Graphical Abstract
These authors contributed equally: Qing Ye, Ying Zhang * Lei Zeng [email protected]
Province, South China University of Technology, 510006 Guangzhou, PR China
* Fei Hang [email protected]
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Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, 510006 Guangzhou, PR China
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School of Material Science and Engineering, South China University of Technology, 510641 Guangzhou, PR China
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National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 510006 Guangzhou, PR China
School of Biomedical Science and Engineering, South China University of Technology, Guangzhou International Campus, 510641 Guangzhou, PR China
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School of Engineering, University of Glasgow, Scotland G11 6BZ, UK
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Key Laboratory of Biomedical Engineering of Guangdong
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Journal of Materials Science: Materials in Medicine (2020)31:77
1 Introduction In recent years, the development of new materials or devices for the bone repairing applications has attracted continuous attentions because of the aging population and the increasing orthopedic surgical demanding [1]. Bone defects, especially those above the critical size which cannot be selfhealed caused by wounds, tumors, or infections, require an osteoconductive and osteoinductive implant to promote tissue regeneration [2]. Although autografts are considered as the “gold standard” in bone repairing, the limited availability and morbidity of the dono
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