Biological Response to Nanosurface Modification on Metallic Biomaterials
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REGENERATIVE BIOLOGY AND MEDICINE IN OSTEOPOROSIS (S BRYANT AND M KREBS, SECTION EDITORS)
Biological Response to Nanosurface Modification on Metallic Biomaterials Patricia Capellato 1
&
Samira Esteves Afonso Camargo 2 & Daniela Sachs 1
Accepted: 9 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose of review New biomaterials for biomedical applications have been developed over the past few years. This work summarizes the current cell lines investigations regarding nanosurface modifications to improve biocompatibility and osseointegration. Recent findings Material surfaces presenting biomimetic morphology that provides nanoscale architectures have been shown to alter cell/biomaterial interactions. Topographical and biofunctional surface modifications present a positive effect between material and host response. Summary Nanoscale surfaces on titanium have the potential to provide a successful interface for implantable biomedical devices. Future studies need to directly evaluate how the titanium nanoscale materials will perform in in vivo experiments. Biocompatibility should be determined to identify titanium nanoscale as an excellent option for implant procedures. Keywords Nanomaterials . Biocompatible . Titanium . Implants . Bone
Introduction Life expectancy has increased over the years due to advances in technology that enhance quality of life. Thus, the demand for orthopedic and dental implants has grown substantially, leading to improved research and development of biomaterials with better mechanical and biological properties [1]. As can be observed, the global orthopedic implants market is expected to reach USD 64.0 billion by 2026 [2]. Additionally, the global dental implants market is projected to achieve USD 13.01 billion by 2023 [3]. Adequate selection and design of materials according to the intended application [4] are essential to prolonging the biomaterial lifetime. This article is part of the Topical Collection on Regenerative Biology and Medicine in Osteoporosis * Patricia Capellato [email protected] 1
Institute of Physics and Chemistry, Unifei- Federal University of Itajubá, Av. BPS, 1303, Itajubá, MG 37500 903, Brazil
2
Restorative Dental Sciences, Division of Prosthodontics, University of Florida, College of Dentistry, Gainesville, FL, USA
However, the ideal metallic material must have a low modulus of elasticity close to bone, tensile strength, fatigue resistance, density, hardness, elongation wear, and corrosion resistance. For many years, dental and orthopedic fields have used stainless steel and cobalt-chrome alloys for their implants [5]. They have shown clinical success because these materials have excellent mechanical properties, high strength, good corrosion resistance, and compatibility with the human body. Nevertheless, titanium and its alloys have been increasingly applied because of similar but improved mechanical and biological properties. Titanium has high biocompatibility and is bioinert. However, the longterm success o
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