Biology and Regulation of Blood-Tissue Barriers

This book was written by many outstanding investigators who have spent decades to study different aspects of blood‑tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, NS. Kline institute jor Psychiatric Research JOHN D. LAMBRIS, University ofPennsylvania RODOLFO PAOLETTI, University of Milan

Recent Volumes in this Series Volume 754 EPIGENETIC ALTERATIONS IN ONCOGENESIS Adam R. Karpf Volume 755 RESPIRATORY REGULATION - CLlNICALADVANCES Mieczyslaw Pokorski Volume 756 RESPIRATORY REGULATION -MOLECULAR APPROACHES Mieczyslaw Pokorski Volume 757 GERM CELL DEVELOPMENT IN C. ELEGANS Tim Schedl Volume 758 ARTERIAL CHEMORECEPTION - FROM MOLECULES TO SYSTEMS ColinA. Nurse Volume 759 POSTTRANSLATIONAL PROTEIN MODIFICATIONS IN THE REPRODUCTIVE SYSTEM Peter Sutovsky Volume 760 REGENERATIVE BIOLOGY OF THE SPINE AND SPINAL CORD Rahul Jandial and Mike Y. Chen Volume 761 OOCYTE BIOLOGY AND FERTILITY PRESERVATION Sam Kim Volume 762 HIV INTERACTIONS WITH DENDRITIC CELLS: INFECTION AND IMMUNITY Li Wu and Olivier Schwartz Volume 763 BIOLOGY AND REGULATION OF BLOOD-TISSUE BARRIERS C. Yan Cheng

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

Biology and Regulation of Blood-Tissue Barriers Edited by

C. Van Cheng, PhD Center for Biomedical Research, Population Council, New York, New York, USA

Springer Science+Business Media, LLC Landes Bioscience

Springer Science+Business Media, LLC Landes Bioscience Copyright ©2013 Landes Bioscience and Springer Seienee+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system; for exclusive usc by the Purchaser of the work.

Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1806 Rio Grande, Austin, Texas 7870 I, USA Phone: 512/6376050; FAX: 512/6376079 http://www.landesbioscience.com The chapters in this book arc available in the Madame Curie Bioscience Database. http://www.landesbioscience.com/curie Biology and Regulation of Blood-Tissue Barriers, edited by C. Yan Cheng. Landes Bioscience 1 Springer Science+Business Media, LLC dual imprint! Springer series: Advances in Experimental Medicine and Biology. ISBN 978-1-4614-4710-8 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, arc in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with resp