Biopharmaceutical Applied Statistics Symposium Volume 3 Pharmaceuti
This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invite
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Karl E. Peace Ding-Geng Chen Sandeep Menon Editors
Biopharmaceutical Applied Statistics Symposium Volume 3 Pharmaceutical Applications
ICSA Book Series in Statistics Series editors Jiahua Chen, Department of Statistics, University of British Columbia, Vancouver, Canada Ding-Geng (Din) Chen, University of North Carolina, Chapel Hill, NC, USA
More information about this series at http://www.springer.com/series/13402
Karl E. Peace Ding-Geng Chen Sandeep Menon •
Editors
Biopharmaceutical Applied Statistics Symposium Volume 3 Pharmaceutical Applications
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Editors Karl E. Peace Jiann-Ping Hsu College of Public Health Georgia Southern University Statesboro, GA, USA
Sandeep Menon Boston University Cambridge, MA, USA
Ding-Geng Chen School of Social Work and Gillings School of Global Public Health University of North Carolina Chapel Hill, NC, USA
ISSN 2199-0980 ISSN 2199-0999 (electronic) ICSA Book Series in Statistics ISBN 978-981-10-7819-4 ISBN 978-981-10-7820-0 (eBook) https://doi.org/10.1007/978-981-10-7820-0 Library of Congress Control Number: 2017964432 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Currently, there are three volumes of the BASS book series, spanning forty-six chapters. Chapters in this book are contributed by invited speakers at the annual meetings of the Biopharmaceutical Applied Statistics Symposium (BASS). Volume 1 is titled Design of Clinical Trials and consists of 15 chapters; Volume 2 is titled Biostatistical Analysis of Clinical Trials and consists of 12 chapters; and Volume 3 is titled Pharmaceutical Applications and consists of 19 chapters. The three volumes include the works o
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