Biophysics of Infection
This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such a
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Mark C. Leake Editor
Biophysics of Infection
Advances in Experimental Medicine and Biology Volume 915
Series editors Irun R. Cohen, Rehovot, Israel N.S. Abel Lajtha, Orangeburg, USA Rodolfo Paoletti, Milan, Italy John D. Lambris, Philadelphia, USA
More information about this series at http://www.springer.com/series/5584
Mark C. Leake Editor
Biophysics of Infection
123
Editor Mark C. Leake Biological Physical Sciences Institute University of York York UK
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-32187-5 ISBN 978-3-319-32189-9 (eBook) DOI 10.1007/978-3-319-32189-9 Library of Congress Control Number: 2016936570 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Traditional insight into the process of infection has stemmed largely either from conventional bulk ensemble average techniques in vitro or from imaging methods either fixed tissue samples or on living cells but restricted to standard limits of optical resolution. However, recently many state-of-the-art interdisciplinary techniques of modern biophysics have emerged which enable us to understand details of the mechanisms of infection far more clearly than before. Essentially, many of these new methods enhance both the spatial and temporal resolutions of data acquisition. This has enabled us to probe dynamic processes of infection directly, and at a precision comparable to the molecular length scale of the key processes involved. These emerging interfacial tools of biophysics include, for example, a range of single-molecule biophysics methods as well as super-resolution microscopy techniques. This volume of The Biophysics of Infection, in the Advances in Experimental Medicine and Biology series includes new protocols, reviews and original r
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