Bisphosphonates
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Bisphosphonates Oesophagitis dissecans superficialis: case report A 27-year-old woman started receiving bisphosphonates [specific drugs, dosages and durations of treatment not stated] for prevention of osteoporosis, and subsequently presented with haematemesis and odynophagia. She reported that she had not been taking adequate water with the tablet. Endoscopy showed mid-oesophageal vertical submucosal haematoma; also observed were vertical fissures and circumferential cracks with whitish, small, peeled mucosa. She was diagnosed with bisphosphonate-associated oesophagitis dissecans superficialis. Bisphosphonates were discontinued, and treatment with a proton-pump inhibitor was started. She recovered rapidly. After a week, a repeat endoscopy confirmed that the oesophagitis was completely healed. Author comment: "Bisphosphonates, as well as potassium chloride and nonsteroidal anti-inflammatory drugs (NSAIDs), are one of the common causes of the esophagitis." Hokama A, et al. Esophagitis dissecans superficialis associated with bisphosphonates. Endoscopy 39 (Suppl. 1): E91, Feb 2007 - Japan
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0114-9954/10/1229-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 22 Nov 2008 No. 1229
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