Bone Toxicology
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is div
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Susan Y. Smith · Aurore Varela Rana Samadfam Editors
Bone Toxicology
Molecular and Integrative Toxicology
Series Editors Jamie DeWitt East Carolina University Greenville, NC, USA Sarah Blossom Arkansas Children’s Hospital Research Institute Little Rock, AR, USA
More information about this series at http://www.springer.com/series/8792
Susan Y. Smith • Aurore Varela Rana Samadfam Editors
Bone Toxicology
Editors Susan Y. Smith Montreal, QC, Canada Rana Samadfam Charles River Preclinical Services Senneville, QC, Canada
Aurore Varela Charles River Preclinical Services Senneville, QC, Canada
ISSN 2168-4219 ISSN 2168-4235 (electronic) Molecular and Integrative Toxicology ISBN 978-3-319-56190-5 ISBN 978-3-319-56192-9 (eBook) DOI 10.1007/978-3-319-56192-9 Library of Congress Control Number: 2017943684 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
Toxicology is often defined as the study of the adverse effects of chemical, physical, or biological agents on organisms and ecosystems. Toxicologists employ a variety of in silico, in vitro, and in vivo experimental approaches to aid in the characterization of these effects. Within the discipline of nonclinical safety assessment of drugs, biotherapeutics, and environmental chemicals, in vivo toxicology studies are used to survey a broad range of organs and tissues to determine if there are any effects on the structure and function of an organ system. While the range of systems examined in these studies is quite broad, much of the focus has been on what are often referred to as major organ systems and there are discrete subdisciplin
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