In Vitro Toxicology Systems

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections

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Anna Bal-Price Paul Jennings Editors

In Vitro Toxicology Systems

METHODS AND

IN

P H A R M A C O LO G Y

T O X I C O LO G Y

Series Editor Y. James Kang University of Louisville School of Medicine Prospect, Kentucky, USA

For further volumes: http://www.springer.com/series/7653

In Vitro Toxicology Systems Edited by

Anna Bal-Price European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra (VA), Italy

Paul Jennings Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria

Editors Anna Bal-Price European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Systems Toxicology Unit Institute for Health and Consumer Protection Joint Research Centre, European Commission Ispra (VA), Italy

Paul Jennings Division of Physiology Department of Physiology and Medical Physics Innsbruck Medical University Innsbruck, Austria

ISSN 1557-2153 ISSN 1940-6053 (electronic) ISBN 978-1-4939-0520-1 ISBN 978-1-4939-0521-8 (eBook) DOI 10.1007/978-1-4939-0521-8 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014935368 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printe