Brachytherapy vs external beam therapy among NSCLC patients undergoing limited surgical resection

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ORIGINAL ARTICLE – CLINICAL ONCOLOGY

Brachytherapy vs external beam therapy among NSCLC patients undergoing limited surgical resection Mausam A. Patel1 · Yama Fazli1 · Sowmya Sivakumar1 · Coleman Dennis1 · Sanjay Maraboyina1 · Arpan V. Prabhu1 · Thomas Kim2  Received: 20 April 2020 / Accepted: 24 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract Purpose  To compare brachytherapy to external beam radiation therapy (EBRT) with respect to overall survival (OS) and disease-specific survival (DSS) among NSCLC patients undergoing limited surgical resection. Methods  All cases of T1-4 N0 M0 NSCLC undergoing limited resection and either brachytherapy or EBRT diagnosed between 2004 and 2014 were extracted from the Surveillance, Epidemiology, and End Results database. Chi-square test and Fisher’s exact analysis were used to analyze categorical variables while Student’s t-test was used to analyze continuous variables. Univariate analysis to assess for differences in survival with respect to covariates was performed with the log-rank test. Multivariable analysis was performed with Cox proportional hazards regression models among the entire cohort and after sub-stratification by T stage. Results  Among 543 patients, 471 underwent EBRT and 72 underwent brachytherapy. Brachytherapy demonstrated improved OS and DSS on univariate analysis as compared to EBRT (p