Brain Glycogen Metabolism
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular
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Mauro DiNuzzo Arne Schousboe Editors
Brain Glycogen Metabolism
Advances in Neurobiology Volume 23
Series Editor Arne Schousboe
More information about this series at http://www.springer.com/series/8787
Mauro DiNuzzo • Arne Schousboe Editors
Brain Glycogen Metabolism
Editors Mauro DiNuzzo Center for Basic and Translational Neuroscience University of Copenhagen Copenhagen, Denmark
Arne Schousboe Faculty of Health and Medical Sciences University of Copenhagen Copenhagen, Denmark
ISSN 2190-5215 ISSN 2190-5223 (electronic) Advances in Neurobiology ISBN 978-3-030-27479-5 ISBN 978-3-030-27480-1 (eBook) https://doi.org/10.1007/978-3-030-27480-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Glycogen is the sole carbohydrate reserve of the brain. Glycogen granules are located in astrocytic processes surrounding neuronal elements, where they can be readily mobilized at times of increased energy need (e.g., during sensory stimulation) or energy failure (e.g., when blood glucose supply is inadequate). Remarkably, the long-held concept that brain glycogen serves solely as an emergency depot has been recently displaced by numerous, unequivocal, and fundamental observations that related its utilization to the support of cognitive functions. Any interference with brain glycogen metabolism affects neurophysiology at multiple hierarchical scales, including cellular (e.g., astrocyte-neuron interactions), network (e.g., neuronal excitability), and system (e.g., learning and memory) levels. Not surprisingly, specific forms of glycogen storage disease are associated with mental retardation, and glycogen has been implicated in aging and several pa
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